Only use the Nix include dirs when no sysroot is configured. --- clang/lib/Driver/ToolChains/Linux.cpp 2018-10-05 18:01:15.731109551 +0200 +++ clang/lib/Driver/ToolChains/Linux.cpp 2018-10-05 18:00:27.959509924 +0200 @@ -641,7 +641,7 @@ // Check for configure-time C include directories. StringRef CIncludeDirs(C_INCLUDE_DIRS); - if (CIncludeDirs != "") { + if (CIncludeDirs != "" && (SysRoot.empty() || SysRoot == "/")) { SmallVector dirs; CIncludeDirs.split(dirs, ":"); for (StringRef dir : dirs) {